This chapter compares and contrasts empirical approaches for partitioning hysteresis loops and predicting creep-fatigue life. The first part of the chapter presents experimental partitioning methods, explaining how they can be used to partition any loading cycle into its basic strain-range components. The methods covered include rapid cycling between peak stress extremes, half-cycle rapid loading and unloading, and variations of the incremental step-stress approach. The methods are then compared based on their ability to predict creep-fatigue life. The chapter goes on from there to describe how fatigue life can be estimated from ductility measurements when cyclic data are unavailable or are likely to change. It also explains how cyclic life is influenced by the time-dependent nature of creep-plasticity and the physical and metallurgical effects of environmental exposure.