Depending on the operating environment and the nature of the applied loading, a structure can fail by a number of different modes, including brittle fracture, ductile fracture, plastic collapse, fatigue, creep, corrosion, and buckling. These failure modes can be broken down into the categories of fracture, fatigue, environmental cracking, and high-temperature creep. This article discusses each of these categories, as well as the benefits of a fitness-for-service approach.