This chapter provides a detailed analysis of the cyclic stress-strain behavior of materials under uniaxial stress and strain cycling. It first considers the case of a stable material under constant-amplitude strain cycling then broadens the discussion to materials that harden or soften with continued strain reversals. It compares and contrasts the response patterns of such materials, explaining how the movement of dispersed particles and dislocations influences their behavior. It then examines the behavior of materials under uniaxial strain reversals of varying amplitude and explains how to construct double-amplitude stress-strain curves that account for complex straining histories. For special cases, those involving complex materials such as gray cast iron or highly complex straining patterns, the chapter presents other methods of analysis, including the rainflow cycle counting method, mechanical modeling based on displacement-limited elements, Wetzel’s method, and deformation modeling. It also explains the difference between force cycling and stress cycling and presents alternate techniques for predicting whether a material will become harder or softer in response to strain cycling.