This chapter provides a quantitative treatment of the cracking mechanisms associated with fatigue, drawing on the principles of fracture mechanics. It explains that although fracture mechanics originated with the aim of understanding sudden and catastrophic crack extension, the main premise of a stress field in the vicinity of the crack also applies to the study of cycle-by-cycle stable crack growth. A detailed review is given of the many developments and discoveries that helped shape the theory and methods collectively defined as crack mechanics, which the authors then employ to analyze the crack growth behavior of various materials, including steels and nonferrous alloys, under constant-amplitude loading. The authors then deal with the effects of complex loading using crack retardation and crack closure models to show how load fluctuations can slow crack growth rates and even cause total crack arrest. They also present the results of a study on crack initiation, propagation, and fracture in circular (rather than rectangular) specimens and a fatigue study on ductile and quasi-brittle materials.