This chapter provides an overview of factors that must be considered in the design of structural components for satisfactory service performance in terms of mechanical behavior of steel castings. The chapter discusses designing against yielding, excessive deflection, and creep and stress rupture. The chapter describes the three main approaches to evaluating and designing structures relative to fatigue resistance: the S-N curve approach for high cycle fatigue, the strain range approach for low cycle fatigue, and the fracture mechanics approach. Two approaches to design against brittle fracture are described, the ductile to brittle transition concept and the fracture mechanics approach. The chapter also discusses several types of corrosion behavior and emphasizes the need to interact with corrosion specialists in the design process. It illustrates the unique advantages that designers may gain by designing components as castings to achieve low stress concentrations economically.