This article explains how to prepare nickel-base alloys for metallographic examination and identifies related processing and imaging challenges. It describes sectioning, mounting, grinding, and polishing procedures along with alternative electropolishing processes. It also provides information on etching and examines the microstructure of Nickel 200, Nickel 270, Duranickel 301, Monel 400, Monel R-405, Monel K-500, and other nickel alloys.