The combination of high strength-to-weight ratio, excellent mechanical properties, and corrosion resistance makes titanium the best material choice for many critical applications. This article commences with a description of the historical perspective of titanium casting technology. It discusses the various types of molding methods, namely, rammed graphite molding, and lost-wax investment molding. The article provides information on the casting design, melting, and pouring practices, and describes the microstructure, hot isostatic pressing, heat treatment, and mechanical properties of Ti-6AI-4V alloy. It also talks about the chemical milling and weld repair, and describes the product applications of titanium alloy castings. Tensile properties, standard industry specifications, and chemical compositions of various titanium alloy castings are tabulated.