Nitinol is frequently used as raw material for cardiovascular endoprosthesis, due to their high biocompatibility and properties such as psedoelasticity. Typically, the highest stress/strain that Nitinol based devices undergo occurs during crimping. These mechanical stresses can affect the functional fatigue behaviors. Nitinol devices are crimped to small diameters to deliver to the anatomical location of interest. Thereby, the microstructural and mechanical changes in Nitinol tubes generated by mechanical load conditions are studied, to monitor the pseudoelastic properties as a function of load time. Consequently, a permanent load test is carried out by means of a fixture with parallel clamps, in order to generate deformation of the cross-sectional area of the tube. The procedure consists of deforming 5 mm long samples with 7 mm outer diameter tubes and a wall thickness of 0.5 mm in straight annealed condition at room temperature. For this test, o-shaped samples of single ingot were analyzed. The test was carried out with strains of 2 %, 4 %, 6 % and 8 % to simulate different device crimp strains. Parts were evaluated after time intervals up to six months under load. Afterwards the geometrical changes of the samples were measured. Additionally, the samples were characterized by DSC and XRD measurements.