This study investigates the influence of build orientation on the high-temperature mechanical properties of IN738LC manufactured via metal laser powder bed fusion (PBF-LB/M). Since the PBF-LB/M layer-wise manufacturing process significantly affects grain morphology and orientation—ranging from equiaxed to textured grains—mechanical properties typically exhibit anisotropic behavior. Samples were manufactured in three build orientations (0°, 45°, and 90°) and subjected to hot tensile and creep testing at 850°C following DIN EN ISO 6892-2 and DIN EN ISO 204 standards. While tensile properties of the 45° orientation predictably fell between those of 0° and 90° orientations, creep behavior over 100-10,000 hours revealed unexpected results: the 45° orientation demonstrated significantly shorter rupture times and faster creep rates compared to other orientations. Microstructural analysis revealed distinct creep deformation mechanisms active within different build orientations, with the accelerated creep rate in 45° specimens attributed to multiple phenomena, particularly η-phase formation and twinning. These findings provide crucial insights into the orientation-dependent creep behavior of PBF-LB/M-manufactured IN738LC components.