As semiconductor devices continue to decrease in size and pitch, demands for accurate microstructural analysis have increased to enable downward scaling. Critical dimension (CD) metrology is key to delivering process insights, but at such scales, rigorous metrology analysis providing high precision data may lack desired throughput. CD measurement using the scanning electron microscope (SEM) is a widely used technique, however, to acquire large area SEM images with high precision, multiple image stitching is currently required. In this paper, a new method for precise and efficient metrology analysis is introduced. This study demonstrates that large area imaging with ultra-high pixel resolution can deliver better throughput while maintaining the same level of precision that can be achieved by the traditional method.