The work presented in this paper addresses a data gap that continues to be a hinderance to users of precipitation modeling tools, particularly those based on Langer-Schwartz theory. Thermodynamic and kinetic data required for precipitation models can be obtained from CALPHAD databases, but interfacial energies between the bulk and precipitate phases are not available for many alloy systems. In this work, a number of matrix-precipitate interfacial energies have been determined for influential precipitates in alloys of industrial importance, for example, carbides in Grade 22 low-alloy steels, delta phase in Ni 625 and 718, S-phase in Al 2024, and Q’ and β’’ in Al 6111.