Skip Nav Destination
Close Modal
Update search
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
Filter
- Title
- Authors
- Author Affiliations
- Full Text
- Abstract
- Keywords
- DOI
- ISBN
- EISBN
- Issue
- ISSN
- EISSN
- Volume
- References
NARROW
Format
Topics
Subjects
Article Type
Volume Subject Area
Date
Availability
1-20 of 24
Biocompatibility
Close
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
1
Sort by
Proceedings Papers
ITSC2023, Thermal Spray 2023: Proceedings from the International Thermal Spray Conference, 54-61, May 22–25, 2023,
Abstract
View Paper
PDF
Infection caused by bacterial contamination is a critical problem challenging the successful use of medical implants in orthopaedic and dental applications. Consequently, medical implants with antibacterial abilities are in high demand. Tantalum and silver have been previously characterized to have excellent biocompatibility and antibacterial ability, but due to their significantly different properties, it is challenging to manufacture Ta-Ag components via thermal processing methods. Herein, by taking advantage of the unique characteristics of cold spray (CS) technology, an antibacterial Ta-Ag coating was successfully fabricated for the first time. In the CS process, blended Ta-Ag powders with different Ag concentrations were used to fabricate CS Ta-Ag coatings. Their antibacterial ability was preliminary tested and deposition behaviour was systematically investigated. The coating significantly reduced the metabolic activity of S. aureus bacteria, and a better deposition efficiency was obtained by blended Ta-Ag powder. It was found that soft Ag could aggregate in the coating and hard Ta particles were prone to rebound, which induced the peening effect for Ag and mass loss of Ta in the final coating Moreover, the clue of metallurgy bonding between Ta and Ag was detected in the region that experienced severe deformation despite their immiscibility.
Proceedings Papers
ITSC 2017, Thermal Spray 2017: Proceedings from the International Thermal Spray Conference, 47-50, June 7–9, 2017,
Abstract
View Paper
PDF
Osteoarthritis in the hip or knee is one of the most common diseases in industrialized countries. The implantation of an endoprosthesis as a joint replacement represents the most effective way to treat serious pathological changes in these joints. The lifetime of an endoprosthesis can be shortened by aseptic inflammation and osteolysis. The main cause for the aseptic inflammations, osteolysis, and thus, the failure of the endoprostheses are abrasion particles of the acetabular cup inlays that are caused by the tribological load of the prosthesis. This research project aims at developing coatings with enhanced tribological behaviour for endoprostheses by an active hydrodynamic lubrication of the joint with synovial fluid. In addition, biocompatibility, as well as the increase of the strength under static and cyclic loading need be realized. In the current approach, a deterministic fluid flow tube structure is formed in a thermally sprayed alumina layer by the introduction of a leachable placeholder. This tube structure allows the transverse transport of the synovial fluid through the alumina layer. Furthermore the synovial fluid can be transported into the lubricating gap of the sliding surfaces by leaving the alumina layer through the porous surface. First results will be presented and the ramifications in correlation to applications will be discussed.
Proceedings Papers
ITSC 2017, Thermal Spray 2017: Proceedings from the International Thermal Spray Conference, 138-141, June 7–9, 2017,
Abstract
View Paper
PDF
The work concerns a study of the properties of cold sprayed Ti coatings. This material is an attractive choice for many applications because it exhibits high strength-to-weight ratios, very good oxidation resistance, corrosion resistance and biocompatibility. Cold spraying is applied to deposit Ti coatings and elements as additive manufacturing process, however it needs higher critical velocity for deposition than other, more ductile metals. Nowadays nitrogen as cheap gas is used as working gas in cold spray process, however application helium as accelerating gas allows to obtain elements with higher strength. It allows to understand the mechanism of cohesion between sprayed particles. In carried out experiment Ti powder with angular shape was applied in the cold spraying process. The coatings were sprayed by means of Impact Innovations 5/8 system with nitrogen and addition of helium onto 7075 Al alloy. The investigations revealed that the cold sprayed Ti coatings with addition of helium as working gas exhibit better mechanical properties, lower porosity and roughness.
Proceedings Papers
ITSC 2017, Thermal Spray 2017: Proceedings from the International Thermal Spray Conference, 814-824, June 7–9, 2017,
Abstract
View Paper
PDF
A bio-implant is a medical device used to support, replace or enhance a biological structure. Bio-implants have incalculable importance for mankind due to their crucial applications in situations like heart diseases, joint replacements, bone fixation and bone replacements etc. The materials which are used to manufacture bio-implants are generally called biomaterials. Corrosion and biocompatibility of biomaterials are the two issues, which are needed to be addressed to enhance the life span of the bio-implants. Various strategies were used to enhance the performance of biomaterials; however surface modification and alloying are the two main strategies among them. To employ these two strategies; various ceramic, metallic and composite materials were utilized as coatings and alloying elements with different biomaterials. Among all these materials, Niobium and Tantalum metals are studied by various researchers and proved to improve the corrosion resistance as well as biocompatibility of the bioimplants. This article gives a systematic overview of research work carried out in the area of bio-implants by utilizing Niobium and Tantalum for the enhancement of corrosion resistance and biocompatibility.
Proceedings Papers
ITSC2016, Thermal Spray 2016: Proceedings from the International Thermal Spray Conference, 132-136, May 10–12, 2016,
Abstract
View Paper
PDF
In this work, micro-plasma spraying is used to produce hydroxyapatite coatings on Ti-6Al-4V substrates. To understand coating formation mechanisms, in-flight particle velocity and surface temperature were monitored under different spraying conditions. XRD measurements show that the resulting coatings have a high degree of crystallinity with little amorphous or metastable phases. Some of the coatings were also found to have a uniformly distributed columnar structure, corresponding to a strong (002) texture and excellent stability in Hanks’ salt solution even after 14 days of immersion.
Proceedings Papers
ITSC2016, Thermal Spray 2016: Proceedings from the International Thermal Spray Conference, 886-893, May 10–12, 2016,
Abstract
View Paper
PDF
SiO 2 -TiO 2 coatings were prepared by atmospheric plasma spraying followed by hydrothermal treatment in a solution of hydrogen fluoride. The as-sprayed coatings mainly consisted of rutile and quartz phases, which remained relatively unchanged during etching. All treated coatings have the typical characteristics of plasma-sprayed deposits, exhibiting rough surfaces with many splats. Differences in surface structure can be observed, however, at the nanoscale, depending on treatment conditions. Treatments of 60 min at 100 °C appear to be most beneficial, resulting in nanoporous coatings that are shown to promote cell proliferation and, in past studies, have been found to improve osteoblast adhesion.
Proceedings Papers
ITSC2012, Thermal Spray 2012: Proceedings from the International Thermal Spray Conference, 219-224, May 21–24, 2012,
Abstract
View Paper
PDF
Bioactive coatings are proven to enhance bone regeneration, implant integration and act as drug-delivery systems following bone replacement surgeries. Polycaprolactone (PCL) was used in this study as coating material due to its superior biocompatibility and biodegradability. Polymethyl-methacrylate (PMMA) was used as an additive in order to improve the flowability of the PCL powder. The processing technique used to obtain polymeric coatings was oxy-acetylene flame spraying. Seeing that biodegradable polymers were not thoroughly investigated in the past, a Design of Experiments (DoE) analysis was necessary in order to understand the effects of spraying parameters on coating characteristics (thickness, roughness, adhesion, wettability) and to be able to optimize the coating properties for specific requirements. The polymer matrix was sprayed onto titanium substrates. The statistical analysis was followed by FTIR spectroscopy, which showed that the coatings underwent little chemical degradation. Finally, biocompatibility tests showed that cells proliferated well on the flame sprayed polymer coatings, which confirms that the coating technique used did not affect the biological performance of the material.
Proceedings Papers
ITSC 2011, Thermal Spray 2011: Proceedings from the International Thermal Spray Conference, 763-768, September 27–29, 2011,
Abstract
View Paper
PDF
The excellent corrosion resistance and biocompatibility of titanium make of it the material to choose for biomedical applications. Cold spraying, as a new coating technique, can be used to deposit protective Ti coatings onto less performing materials such as stainless steel and Co-Cr alloys, commonly used for biomedical implants. In addition, Cold Spray has the advantage, in comparison with conventional thermal spray techniques, to permit the deposition of oxygen-sensitive materials. In this study, Cold Sprayed Ti coatings were prepared on Co-Cr alloy substrates by using different spray process conditions. The microstructure of coatings was observed by SEM and the inner porosity was estimated by image analysis. Oxygen and nitrogen contents were investigated on a set of free standing deposits obtained using different process parameters. In the same way, the roughness and microhardness of deposits, such as the adhesion strength with the substrate, were measured. Finally, the corrosion performance of the coatings was evaluated by mean of open circuit potential measurement (OCP) and potentiodynamic polarizations scans. The electrochemical response was therefore discussed and compared to the corrosion behaviour of the Co-Cr alloy substrate and the bulk Titanium.
Proceedings Papers
ITSC 2011, Thermal Spray 2011: Proceedings from the International Thermal Spray Conference, 835-839, September 27–29, 2011,
Abstract
View Paper
PDF
Cold Spraying, as a novel Thermal Spraying Technology can deposit a wide range of ductile materials on different substrates; a problem arises when the objective is to use this technology to deposit brittle materials such as ceramics in applications where melting must be avoided. One example is when spraying Bio-Ceramics, in which particle´s melting often leads to changes in physical and chemical properties and subsequently resulting in unknown variations in the coating´s biocompatibility. While Non-Ductile Materials can only be deposited if they are co-cold-sprayed with a ductile (matrix) material a Metal-Ceramic Powder Composite must be used for these objectives. The goal of this paper is to show a transient Non-Linear Dynamics Computational Analysis of a Metal- Ceramic Powders Composite impacting a metallic substrate by the means of Cold Spraying Technology; all this in order to understand the formation of cold sprayed composite coatings while comparing them with experimental results and using ANSYS-AUTODYN© to assess the suitability of this spraying technology for coating special application substrates.
Proceedings Papers
ITSC 2011, Thermal Spray 2011: Proceedings from the International Thermal Spray Conference, 1225-1228, September 27–29, 2011,
Abstract
View Paper
PDF
Biocompatibility of hydroxyapatite (HAp) coatings have led to its use in a wide range of applications in both dentistry and orthopaedics. The plasma spraying method is the most commonly used method for the production of Hap (Ca 5 (PO 4 ) 3 OH) coatings on Ti alloys. When HAp is injected into the plasma jet, several phases can coexist under the effect of a temperature gradient occurring in the bulk of the particle. The amounts of residual compounds, amorphous and recrystallized phases are related to the conditions of spraying such as gas flow rates, feed rate, spray distance, plasma current and cooling effect. Plasma-sprayed HAp coatings were analyzed by X-ray diffraction and electron microscopy.
Proceedings Papers
ITSC 2009, Thermal Spray 2009: Proceedings from the International Thermal Spray Conference, 386-390, May 4–7, 2009,
Abstract
View Paper
PDF
In this study, vacuum plasma spraying was used to apply hydroxyapatite-silver composite coatings on titanium substrates, which were then exposed to E. coli, Pseudomonas aeruginosa , and Staphylococcus aureus . The coatings exhibited excellent antibacterial performance ( K > 95%) against all three strains, attributed to the release of silver ions. Cytotoxicity, hemolysis, and simulated body fluid immersion tests showed that added silver affects neither the biocompatibility nor bioactivity of the hydroxyapatite, one of the most widely used medical implant materials due to its close chemical structure with natural bone.
Proceedings Papers
ITSC 2007, Thermal Spray 2007: Proceedings from the International Thermal Spray Conference, 371-376, May 14–16, 2007,
Abstract
View Paper
PDF
New advanced polymeric biomaterials such as implantable poly(etheretherketone) (PEEK) are changing the face of the implantable medical device industry. Due to its bioactive behavior in vivo, hydroxyapatite (HA) coatings are used to improve the bone growth and to repair around metallic implant. The objective of this work is to study the feasibility of plasma sprayed hydroxyapatite coating on PEEK material. Different PEEK (unfilled and composite) specimens were successfully coated with a 150 µm thick coating. Chemical and crystallographic compositions, adhesions and microstructures of HA coatings on PEEK and on Ti-6Al-4V were compared. The results showed that the structure of HA coatings were appreciably equivalent. Mechanical tests showed that the plasma spraying process did not severely degrade the initial properties of the PEEK substrate.
Proceedings Papers
ITSC 2007, Thermal Spray 2007: Proceedings from the International Thermal Spray Conference, 385-388, May 14–16, 2007,
Abstract
View Paper
PDF
In this work, the plasma sprayed titania coatings were treated by H 2 SO 4 for 24h at room temperature to improve the biological properties. The bioactivity was measured by simulated body fluid soaking test, and the biocompatibility was evaluated by quantifying the grafted collagen amount and in vitro cell culture test. The results showed that titania coatings treated by 0.1M and 1M H 2 SO 4 can induce bone-like apatite formation after immersion in SBF for 28 days, while the titania coating treated by 0.01M H 2 SO 4 can not. H 2 SO 4 treatment can promote the grafting of collagen on titania coatings. The in vitro cell culture test confirmed that collagen improved the cellular adhesion and proliferation on titania surface. In conclusion, a certain concentration of H 2 SO 4 treatment is beneficial in improving the bioactivity and biocompatibility of plasma sprayed titania coatings.
Proceedings Papers
ITSC 2007, Thermal Spray 2007: Proceedings from the International Thermal Spray Conference, 401-404, May 14–16, 2007,
Abstract
View Paper
PDF
Plasma sprayed hydroxyapatite coating can bond to living bony tissue, and it is being widely used in clinical application. The problem of hydroxyapatite coating on metal substrate may mainly come from the instability of coating-substrate interface and the unstable duration of coating in the presence of body fluid. Therefore, it is desirable to develop newly bioactive coatings with good bioactivity and mechanical properties. In this paper, new progress in plasma sprayed bioactive coatings at Shanghai Institute of Ceramics are reviewed. The novel coatings including wollastonite, dicalcium silicate, diopside and titania were deposited. All the bioactive coatings mentioned above form a bone-like apatite layer on their surface immersed in simulated body fluid, indicating their good bioactivity. The formation of bone-like apatite is induced by Si-OH and Ti-OH on the surface of coatings. The results of cell culture test indicated that novel coatings can enhance osteoblast adhesion, proliferation and differentiation, indicating their good biocompatibility.
Proceedings Papers
ITSC 2006, Thermal Spray 2006: Proceedings from the International Thermal Spray Conference, 35-40, May 15–18, 2006,
Abstract
View Paper
PDF
HA-coatings have been widely used in human surgery to increase the biocompatibility of metal alloys used as arthroplasty material. Their characteristics are of fundamental importance for their behaviour in the organism and in particular their degradation rate. We had the opportunity to perform histological analysis of human femurs containing well functioning HA-coated hip prostheses implanted for various periods from a few days up to several years. It was showed that the coatings exhibit degradation signs very early after the implantation and the released debris have different fates depending their size and shape. These results can be compared with those obtained in animals or in vitro. It was shown that the bone tolerate the contaminant phases which can be formed during the plasma spraying.
Proceedings Papers
ITSC 2006, Thermal Spray 2006: Proceedings from the International Thermal Spray Conference, 41-46, May 15–18, 2006,
Abstract
View Paper
PDF
Nanostructured titania (TiO 2 ) coatings were produced by high velocity oxy-fuel (HVOF) spraying. They were engineered as a possible candidate to replace hydroxyapatite (HA) coatings produced by air plasma spray (APS) on implants. They exhibited mechanical properties, such as hardness and bond strength, much superior to those of APS HA coatings. In addition to these characteristics, the surface of the nanostructured coatings exhibited regions with nanotextured features originating from the semi-molten nanostructured feedstock particles. This nanotexture is considered an asset, due to its better interaction with the adhesion proteins of the osteoblast cells, such as fibronectin, which exhibit dimensions in the order of nanometers. Osteoblast cell culture demonstrated that this type of coating supported osteoblast cell growth and did not negatively affect cell viability.
Proceedings Papers
ITSC 2006, Thermal Spray 2006: Proceedings from the International Thermal Spray Conference, 53-58, May 15–18, 2006,
Abstract
View Paper
PDF
In this work, a TiO 2 coating with nanostructured surface was obtained through plasma sprayed nano-sized TiO 2 powder. Its bonding strength onto Ti-6Al-4V substrate is high up to 38 MPa. At same time, we have successfully improved the bioactivity of plasma sprayed TiO 2 coating with nanostructured surface using hydrogen ion implantation and UV illumination. Bone-like apatite can form on the surface of the post-treated TiO 2 coatings after they are soaked in simulated body fluid for a period of time. Introduction of surface bioactivity (bone conductivity) to plasma-sprayed TiO 2 coatings which are generally recognized to have excellent biocompatibility and corrosion resistance as well as high bonding to titanium alloys makes them more superior than many current biomedical coatings such as plasma-sprayed hydroxyapatite.
Proceedings Papers
ITSC 2005, Thermal Spray 2005: Proceedings from the International Thermal Spray Conference, 726-731, May 2–4, 2005,
Abstract
View Paper
PDF
Excellent biocompatibility of hydroxyapatite (HA) is the main reason of application plasma-sprayed coatings onto orthopedic prostheses. A careful optimization of spray parameters is necessary to avoid thermal decomposition of HA onto less biocompatible products such as e.g. tricalcium phosphate, tetracalcium phosphate, calcium oxide and amorphous calcium phosphates. The spray parameters influence considerably the decomposition and the present study is devoted to understand this influence using on an experimental way. The design of experiments (DOE) was made using two-level 2N plan of experiments (N=5). In total, 32 experiments of spraying were carried out by varying following operational parameters: (i) composition of plasma working gases; (ii) electric power input; (iii) art of spraying (into water or onto substrate); (iv) carrier gas flow rate and; (v) art of injection (external and internal). Plasma-sprayed coatings and powders were analyzed by Fourier Transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). The X-ray diagrams enabled to find the content of crystal phases. The content was a first response function described by a polynomial regression equation. The morphology of obtained deposits was also characterized using Scanning Electron Microscope (SEM). Their porosity was estimated using image analysis of coatings cross section images.
Proceedings Papers
ITSC 2004, Thermal Spray 2004: Proceedings from the International Thermal Spray Conference, 157-162, May 10–12, 2004,
Abstract
View Paper
PDF
Nanostructured and conventional hydroxyapatite (HA) feedstocks were evaluated to determine the effects of feedstock structure on the processing, properties and performance of coatings produced by atmospheric plasma spraying. The structure of the feedstocks was characterized using scanning electron microscopy (SEM). It was found that the nanostructured feedstock particles were formed by an agglomeration of nanostructured fibers having dimensions of less than 500 nm in length and below 100 nm in width. The average particle temperatures and velocities were measured during plasma spraying and found to be ~2650°C and ~315 m/s for the both feedstocks. The mechanical, microstructural and biocompatibility characteristics of coatings deposited on Ti-6Al-4V substrates were evaluated. The hardness was measured using Vickers indentation. The bond strength was determined via a tensile adhesion test. Microstructural characteristics of the coatings and their porosity levels were evaluated using SEM and image analysis. Phase analysis was carried out via X-ray diffraction (XRD) and aided by energy-dispersive X-ray analysis (EDS). The in-vitro behavior of these coatings was investigated in a simulated physiological solution in an attempt to simulate the environment of an implant in the human body.
Proceedings Papers
ITSC 2004, Thermal Spray 2004: Proceedings from the International Thermal Spray Conference, 215-218, May 10–12, 2004,
Abstract
View Paper
PDF
Wollastonite and its composite coatings with zirconia and titania have been deposited by plasma spraying. The bioactivity of coatings was evaluated using a simulated body fluid soaking test. The fetal rat’s osteoblasts were seeded on the surface of the coatings to examine their biocompatibility. The SEM and XRD technologies were used to examine the morphologies, structure and composition of the surface of the coatings soaked in the simulated body fluid. The results obtained showed that carbonate-containing hydroxyapatite was formed on the surfaces of wollastonite, wollastonite/ZrO 2 and wollastonite/TiO 2 coatings, while was not formed on the surfaces of ZrO 2 and TiO 2 , indicating the wollastonite improved the bioactivity of ZrO 2 and TiO 2 coatings. Osteoblasts are able to survive and proliferate on the surfaces of wollastonite, wollastonite/ZrO 2 and wollastonite/TiO 2 coatings. It is enough to prove that these coatings possess excellent biocompatibility.
1