This research aims at introducing new biodegradable/non-biodegradable materials (biopolymers) to the existing Hydroxyapatite (HA)-titanium combination or as a single coating in order to overcome some of the limitations of HA coatings. Biopolymers can act as drug carriers for a localised drug release following implantation; they can also have a structural role by improving the mechanical performance of implants at the bone –implant interface. The proposed materials consisted of biodegradable and non-biodegradable polymers widely used as drug delivery systems: polymethylmethacrylate and polyhydroxybutyrate 98%/ polyhydroxyvalerate 2%. The method used to apply the polymeric powders was oxygen/acetylene flame spraying, due to its superior mechanical advantages over other techniques. Screening tests were used to determine the suitable range of spraying parameters, followed by optimisation to understand of the effects of spraying parameters on coating characteristics (thickness, roughness, adhesion, wettability), in order to obtain an optimal coating design. The polymers were sprayed onto bare titanium substrates. FTIR results showed that the coatings underwent little chemical degradation. Biocompatibility tests showed that cells proliferated well on flame sprayed polymer coatings, which confirms that the coating technique used did not affect the biological performance of the material.