A mathematical model is developed to analyze thermo-physical phenomenon within an individual solution precursor droplet travelling in the high temperature plasma jet. The model involves the motion and evaporation of the droplet and the heat and mass transfer within the droplet. The influence of Stefan flow and the variable physical properties of the environment gas around the droplet are considered. The internal circulation due to the relative velocity between the droplet and the plasma jet, which can be described by the Hill’s spherical vortex, is considered as well. The trajectory, temporal droplet surface temperature and radius variation are predicted. The temperature and concentration distribution inside the droplet as well as the difference between the droplets with different injection parameters are presented.