Recently, an advanced technique was developed to fabricate sandwich structures for high temperature applications by depositing alloy 625 skins on Ni alloy foam core by thermal spraying. This study tries to utilize an analytical model to estimate the mechanical performance of these structures based on the mechanical properties of the constituents. The mechanical behavior of the Ni alloy foam is assessed via compression testing, while tensile tests are used in the case of the alloy coating. The flexural rigidity of the sandwich structure is calculated using analytical models and experimentally obtained elastic moduli of the alloy 625 coating and Ni alloy foam. The model is also used to calculate the flexural rigidity of sandwich samples with different skin thicknesses to check the accuracy of the model and to understand the effect of skin thickness on the predicted mechanical performance of sandwich structures. The effect of heat treatment on the mechanical behavior of sandwich structures is investigated as well.