Molybdenum disilicide (MoSi2) is a suitable material for high temperature applications especially because of its excellent high temperature oxidation resistance. For several high temperature applications MoSi2 shows high potential to be used as a protective coating. The oxidation behaviour of HVOF sprayed MoSi2 coatings is studied at 1500 °C. The oxidation tests are carried out in a simultaneous thermogravimetric device and the mass change is measured in dependence on the oxidation time. The microstructure of the coatings before and after oxidation is examined by X-ray diffraction analysis (XRD), scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDXS). The mass of the coating increases according to a parabolic function. During the oxidation test the microstructure changes significantly from a typical thermal spray coating microstructure with lamellae, pores and a phase mixture of MoSi2 and Mo5Si3 to a two phase system with sharply separated grain boundaries. On the surface of the coating a silicon dioxide layer with a thickness of less than 10 µm is formed.