This paper analyzes the through-put time and output of fault isolation and failure analysis (FI/FA) flows on state-of-the-art microprocessors. An average reduction in through-put time of 40% was demonstrated with a shortened FI/FA flow while still maintaining a high success rate. The direct FA/nano-probing flow which was utilized by up to around 90% of the fail cases omitted the optical fault isolation step and instead expanded the use of plasma FIB, nano-probing and electrical isolation techniques (such as diagnosis tools). The end result is shorter through-put time and higher FI/FA volume which is important in order to achieve a faster production ramp. In the paper two cases studies are presented to demonstrate the new efficient FI/FA techniques.