This paper outlines a methodology which accurately identifies fault locations in Mixed Signal Integrated Circuits (ICs). The architecture of Mixed Signal ICs demands more attention during failure analysis because of the complexity of measuring both the analog and digital signals in a compact circuit. In this paper, the GHz range of data signal or radio frequency (RF) signal from an internal IC circuit will be extracted by a high-impedance active single probe in order to find the internal IC circuit failure locations. The advantages of using a single probe is that it can maneuver to extract data almost anywhere in the circuit, providing ranges of bandwidth in GHz with no loading effect on the circuits during measurement. The process of preparing a sample and extracting a signal will be described.