This article focuses on the pneumatic extrusion-based system for biomaterials. It provides an overview of additive manufacturing (AM) processes, followed by sections covering steps and major approaches for the 3D bioprinting process. Then, the article discusses the types, processes, advantages, limitations, and applications of AM technology and extrusion-based approaches. Next, it provides information on the research on extrusion-based printing. Finally, the article provides a comparison of the extrusion-based approach with other approaches.

This article begins with a description of extrusion-based bioprinting for tissue scaffold fabrication. It also examines various extrusion-based bioprinting processes and related tissue scaffolding strategies, presents the selection criteria of various bioinks with various polymers and their printed scaffolds for applications in tissue engineering and regenerative medicines, and provides future research recommendations to address the shortcomings and issues found in current extrusion-based bioprinting processes.

Seals are mechanical components that prevent the leakage, diffusion, transfer, or mixing of different liquid, gas, solid, and multiphasic substances. This article begins by discussing the classifications of seals: static and dynamic. Static seals involve both self-energizing elastomeric materials such as O-rings, which merely react to a sealed fluid pressure, and passive materials that require clamping forces to achieve sealing, such as gaskets. The types of dynamic seals include rotary seals and reciprocating seals. The article describes the factors affecting seal wear and failure. It provides a list of some common seal wear modes and failures, namely abrasion, cavitation damage, chemical attack, compression set, corrosion, damage during abrupt decompression, dieseling damage, extrusion damage, installation damage, spiral or rolling damage, and vaporization damage. The article concludes with specific recommendations for reducting of seal friction and wear.

Aluminum and aluminum alloys are very suitable for extrusion and many types of profiles can be produced from easily extrudable alloys. This article lists the basic characteristics of aluminum and its alloys. It tabulates the aluminum extrusion alloys by series and lists the typical applications for 6xxx series aluminum extrusions. The article discusses three broad categories of extrusion profiles: solid profile, hollow profile, and semi hollow profile. It provides information on weldability and machinability, which are often considered in profile design and product performance. The article discusses different aluminum extrusion processes, such as the direct extrusion process and the indirect extrusion process. It schematically illustrates the plotting of flow stress and extrudability for several types of aluminum alloys. The article concludes with information on the heat treatment and precipitation hardening for alloys, such as 2xxx, 6xxx, and 7xxx.

Material extrusion systems are the most common types of additive manufacturing systems, also known as three-dimensional (3D) printers. This article focuses on the general 3D printing processes as can be demonstrated and manipulated in desktop printers. The discussion includes details of the components involved in material extrusion as well as the melt extrusion solidification (during cooling) process, the underlying mechanism of road bonding, and the factors affecting good part quality. The discussion also covers support material, postprocessing, and road-quality considerations and the addition of infill in melt extrusion to the hollow spaces inside an object to give it structural strength. Information is also provided on different materials and associated material properties that affect the rate the printer is able to advance and retract material, thereby affecting the quality and rate at which a part is printed. The final section provides information on the mechanism of viscous extrusion 3D printing.

Plastic deformation of one or both metals is required to obtain bonding in cold welding. This article presents a theoretical model, to explain the bond strength, based on metallographic studies and continuum mechanical analysis of the local plastic deformation in the weld interface. It describes the bonding mechanisms, with illustrations. The article discusses the alternative methods of surface preparation and quality control of the weld interface of a cold weld. It concludes with a description of a variety of metal-forming processes suitable for production of cold welds, namely, rolling, indentation, butt welding, extrusion, and shear welding.

The field of bioprinting is a subset of additive manufacturing (AM) that is rapidly expanding to meet the needs of regenerative medicine and tissue engineering. Bioprinting encompasses a broad spectrum of issues, from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human-scale tissue structures, and from building cell/tissue/organ-on-a-chip to biomanufacturing of multicellular engineered living systems. This article focuses on two challenges regarding bioprinting: bioinks and crosslinking. It describes the methods for characterizing the performance of bioink formulations and the effectiveness of crosslinking strategies. The topics covered include modalities of bioprinting, characteristics of bioink, rheological properties of bioink sols, rheological measurements, mathematical models of bioink rheology, postfabrication polymer network mechanics, mechanical properties of crosslinked bioinks, and printability of bioinks. Finally, specific strategies used for crosslinking bioinks, as well as some emerging strategies to further improve bioinks and their crosslinking, are summarized.

Cold pressure welding can be accomplished by deforming in a lap or butt configuration, drawing, extrusion, and rolling. This article provides a discussion on cold pressure lap welding, cold pressure butt welding and cold pressure welding in drawing process with illustrations. It provides information on the combinations of metals that can be successfully cold welded.

This article is a review of the material extrusion-based ceramic additive manufacturing (MECAM) processes. The discussion begins with details of extrusion with filament and paste, covering the most popular variants of paste extrusion-based MECAM techniques that can be differentiated based on paste type and the method of shape retention of the deposited layer: extrusion freeforming, robocasting ceramic on-demand extrusion, and freeze-form extrusion fabrication. The article then focuses on post-processing considerations and the mechanical properties of sintered ceramic parts. It concludes with information on innovation opportunities in ceramic additive manufacturing, such as incorporating UV-curing and gelation in the process and producing geometrically complex structures from shapeable green bodies.

Bioprinting has been advancing in the field of tissue engineering as the process for fabricating scaffolds, making use of additive manufacturing technologies. In situ bioprinting (also termed intraoperative bioprinting) is a promising solution to address the limitations of conventional bioprinting approaches. This article discusses the main approaches and technologies for in situ bioprinting. It provides a brief overview of the bioprinting pipeline, highlighting possible solutions to improve currently used approaches. Additionally, case studies of in situ bioprinting are provided and in situ bioprinting future perspectives are discussed.

Ingot casting is the vital conduit between molten metal provided by primary production and recycling, and the manufacture of aluminum and aluminum alloy products. This article discusses various ingot forms, such as remelt ingot, billets, ingots for rolling, fabricating ingot, and particle ingot and powder. It describes the molten metal processing and ingot casting process in terms of open-mold casting and direct chill process. The article examines the continuous processes that provide commercial alternatives to conventional ingot casting. It reviews the postsolidification processes in terms of stress relief, homogenization, and scalping. The article concludes with a discussion on safety limited to ingot casting.

The application of three-dimensional printers can be revolutionary as a tool for the customization and personalization of pharmaceutical dosage forms. The areas of 3D printing applicable to pharmaceutical manufacturing can be segregated into three categories: extrusion technologies, powder-bed fusion, and stereolithography. Common extrusion-based technologies are fused deposition modeling and pressure-assisted microsyringe; powder-bed fusion is separated by binder jet and selective laser sintering. The synergies between pharmaceutical, or active pharmaceutical ingredient (API), and polymer printing are discussed in this article, with particular attention to how the incorporation of small-molecule APIs changes the material selection, design considerations, processing parameters, and challenges associated with each technology.

Ingot casting is the vital conduit between molten metal provided by primary production and recycling and the manufacture of aluminum and aluminum alloy products. A number of ingot casting processes have been developed to ensure the soundness, integrity, and homogeneity required by downstream manufacturing processes. This article starts with a review of the different forms of ingot and the molten-metal processing techniques involved in ingot casting. It then describes the open-mold casting and direct chill (DC) ingot casting processes. The process variations and solidification in the DC process are summarized. The article explains continuous processes, namely, twin-roll strip casting, slab casting, and wheel-belt processes. It concludes with information on postsolidification processes, including stress relief and scalping, and a discussion of safety practices for ingot casting.

This article introduces the basic characteristics, processes, and product forms associated with the five major categories of aluminum wrought products, namely, flat-rolled products (sheet, plate, and foil); rod, bar, and wire; tubular products; profiles; and forgings. It summarizes the various product forms in which commonly used wrought aluminum alloys are available. The article also provides design guidelines for aluminum extrusions and discusses various forming methods.

Thermoforming is a manufacturing process in which thermoplastic sheets are heated, softened, clamped onto a mold, and made to conform to the shape of the mold or forming tool. It is ideally suited to large-volume runs of small items. This article focuses on major phases of thermoforming, namely, sheet transportation, heating, forming/cooling, and trimming, and different thermoforming techniques: basic female forming; basic male forming; matched-mold thermoforming; plug-assist thermoforming; pressure bubble plug-assist vacuum thermoforming; vacuum snapback thermoforming; air-slip thermoforming; and trapped-sheet, contact heat, and pressure thermoforming. It concludes with a discussion on machines and the economic concerns of thermoforming.