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hydroxyapatite
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Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006886
EISBN: 978-1-62708-392-8
... Abstract Hydroxyapatite (HA) is one of the most popular materials in tissue scaffold engineering due to its similarity to the nature of human bone; it accounts for more than half of the total weight of the latter. Selective laser sintering (SLS) is an additive manufacturing method that is used...
Abstract
Hydroxyapatite (HA) is one of the most popular materials in tissue scaffold engineering due to its similarity to the nature of human bone; it accounts for more than half of the total weight of the latter. Selective laser sintering (SLS) is an additive manufacturing method that is used in producing tissue engineering parts from HA feedstocks. This article provides a brief overview of the process itself, along with a detailed review of HA-based tissue engineering applications using SLS. Discussion on the various polymer composites is presented. A detailed overview of selected publications on HA-based SLS studies is listed, which provides insight regarding technical aspects of processing HA powder feedstocks.
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in Binder Jet Additive Manufacturing of Biomaterials
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 9 (a) Graph showing osteoblast proliferation concerning hydroxyapatite (HA) and tricalcium phosphate (TCP) in the composition at days 1, 4, and 7, respectively, with the presence of macropores. OD, optical density. (b) Alkaline phosphatase (ALP) gene expression on 3D-printed HA/β-TCP
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in Selective Laser Sintering of Hydroxyapatite-Based Materials for Tissue Engineering
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 3 (a) Scanning electron microscopy (SEM) image of nano-hydroxyapatite powder. (b) Optical image of printed scaffold. (c) to (e) SEM images of printed scaffold. Source: Ref 58
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in Production of Dicalcium Phosphate with Controlled Morphology and Reactivity
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 14 Reaction scheme of the effect of hydroxyapatite (HAp) on the reaction of dicalcium phosphate dihydrate (DCPD) with fluoride ions. (A) Mixing; (B) Coating. Ca 2+ , calcium ions; DCPD, dicalcium phosphate dihydrate; FAp, fluorapatite; HAp, hydroxyapatite; PO 3- 4 , phosphate ions
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Published: 12 September 2022
Fig. 11 Example of laser-patterned hydroxyapatite coating on AZ31B magnesium biomedical alloy. Source: Ref 64
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in Stereolithographic Additive Manufacturing of Biological Scaffolds
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 3 Acryl composite and hydroxyapatite component fabricated by stereolithographic additive manufacturing. (a) Composite precursors dewaxed in an air atmosphere at 600 °C (1112 °F) for 2 hours. (b) Ceramic components sintered at 1250 °C (2282 °F) for 2 hours. Part accuracies were improved
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in Stereolithographic Additive Manufacturing of Biological Scaffolds
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 4 Microstructure of hydroxyapatite scaffold observed using scanning electron microscopy
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in Stereolithographic Additive Manufacturing of Biological Scaffolds
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 11 Microstructural morphologies in hydroxyapatite lattices. Microscopic fields of (a) 1200, (b) 1250, and (c) 1300 °C (2192, 2282, and 2372 °F) were observed after sintering. Fine crystal grains were homogeneously distributed (b) without micropores generation, compared with (a) and (c).
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in Biomedical Coatings Made by Thermal Spraying for Orthopaedic Joint Applications
> Thermal Spray Technology
Published: 01 August 2013
Fig. 1 Artificial hip joint on which titanium (Ti) and hydroxyapatite (HA) coatings were applied by plasma spraying for promotion of bone growth. UHMWPE, ultrahigh-molecular-weight polyethylene. Courtesy of Stryker Howmedica Osteonics
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in Biomedical Coatings Made by Thermal Spraying for Orthopaedic Joint Applications
> Thermal Spray Technology
Published: 01 August 2013
Fig. 3 Plasma-sprayed titanium bond coat and top hydroxyapatite (HA) coating on carbon-fiber-reinforced polyetheretherketone (CF-PEEK) acetabular cup. Courtesy of Elsevier Ltd. Source: Ref 7
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in Biomedical Coatings Made by Thermal Spraying for Orthopaedic Joint Applications
> Thermal Spray Technology
Published: 01 August 2013
Fig. 4 Hydroxyapatite crystal. SBF, simulated body fluid. Courtesy of A. Cuneyt Tas
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in Biomedical Coatings Made by Thermal Spraying for Orthopaedic Joint Applications
> Thermal Spray Technology
Published: 01 August 2013
Fig. 5 Hydroxyapatite (HA) phase diagram in 500 mm mercury column pressure. Courtesy of Elsevier Ltd. Source: Ref 9
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in Biomedical Coatings Made by Thermal Spraying for Orthopaedic Joint Applications
> Thermal Spray Technology
Published: 01 August 2013
Fig. 6 Solution-deposited hydroxyapatite (HA) coating onto porous CoCr-beaded surface on the backside of a tibia tray and femoral components for an artificial knee. Courtesy of Stryker Howmedica Osteonics
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Published: 15 June 2020
Fig. 13 Hydroxyapatite powder coated with maltodextrin to enhance sinterability. (a) Individual particles coated at different concentration levels. (b) Micrograph of individual sintered particle. Source: Ref 64
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Published: 15 December 2019
Fig. 52 Hydroxyapatite minerals on a polymer substrate imaged with the (a) scanning electron microscope and (b) helium focused ion beam
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in Stereolithographic Additive Manufacturing of Biological Scaffolds
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 10 Graded profiles introduced into precursor and component. Acryl composites (a) dewaxed and (b) sintered into hydroxyapatite scaffold in an air atmosphere.
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in Selective Laser Sintering of Hydroxyapatite-Based Materials for Tissue Engineering
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 4 Biomimetic, hierarchical approach in fabricating microsphere-based hydroxyapatite/polycaprolactone scaffolds via selective laser sintering (SLS). Source: Ref 80
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Published: 12 September 2022
Fig. 12 Scanning electron micrograph showing precipitation of crystalline apatite minerals on hydroxyapatite-coated Ti-6Al-4V upon 24 h immersion in simulated body fluid. Source: Ref 92
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in Selective Laser Sintering of Hydroxyapatite-Based Materials for Tissue Engineering
> Additive Manufacturing in Biomedical Applications
Published: 12 September 2022
Fig. 5 Optical images of the fabricated scaffolds. (a) Poly-L-lactide acid (PLLA)/nano-hydroxyapatite (nHA). (b) PLLA/polyglycolic acid (PGA)/nHA. (c) PGA/nHA. Source: Ref 94
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Published: 01 June 2012
Fig. 8 Solubility diagram of some calcium phosphates. DCPA, dicalcium phosphate anhydrous; DCPD, dicalcium phosphate dehydrate; OCP, octacalcium phosphate; α- and β-TCP, tricalciumphosphate; HA, hydroxyapatite; and TTCP, tetracalcium phosphate. Source: Ref 40
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