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high-throughput drug screening
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Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006892
EISBN: 978-1-62708-392-8
... Abstract Microvalve jetting, with its advantages of low cost, ease of operation, high printing speed, and ability to process living cells with high viability, has been primarily used for fabricating high-throughput drug-screening models, in vitro cellular structures for fundamental cell biology...
Abstract
Microvalve jetting, with its advantages of low cost, ease of operation, high printing speed, and ability to process living cells with high viability, has been primarily used for fabricating high-throughput drug-screening models, in vitro cellular structures for fundamental cell biology research, and cell-laden structures for regenerating tissues or organs in the human body after disease or trauma. This article provides an overview of microvalve jetting of biomaterials, including operational parameters. The jetting technologies covered are inkjet printing, microvalve jetting, and laser-assisted jetting. The parameters covered include nozzle size (nozzle inner diameter), pneumatic pressure, valve-opening time, and printing speed of microvalve jetting. Subsequently, the article discusses biomaterials for microvalve jetting in terms of biomaterial definition, required properties for a suitable biomaterial, currently used biomaterials, and cells and cellular structures. Additionally, applications of microvalve jetting in biomedical engineering are presented, which include cellular and RNA analysis, high-throughput drug screening, and tissue engineering.
Image
Published: 12 September 2022
Fig. 4 High-throughput production via microvalve jetting of alginate-embedded multicellular spheroids for cancer drug screening. Source: Ref 15 . Creative Commons License (CC BY-NC-ND 4.0), https://creativecommons.org/licenses/by-nc-nd/4.0/
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Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006858
EISBN: 978-1-62708-392-8
..., and tissue formation. Successful in vitro conditioning of the desired cell types plays a key role in achieving the final vascularized tissue, metastatic models, multicellular tissues, or scaffolds for high-throughput drug screening. Figure 1 depicts the overall process flow involved in the majority...
Abstract
Three-dimensional plotting of biomaterials (also known as bioprinting) has been a major milestone for scientists and engineers working in nanobiotechnology, nanoscience, and nanomedicine. It is typically classified into two major categories, depending on the plotting principle, as contact and noncontact techniques. This article focuses on the working principles of contact and noncontact printing methods along with their advantages, disadvantages, applications, and challenges. Contact printing methods include micro-plotter, pen printing, screen printing, nanoimprint printing, flexography printing, and gravure printing. Noncontact printing methods include extrusion printing, droplet printing, laser-based polymerization, and laser-based cell transfer. The wide variety of printable biomaterials, such as DNA, peptides, proteins, lipids, and cells, also are discussed.
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006900
EISBN: 978-1-62708-392-8
... (>100 μm) Requires drying step after printing Potential risks with material flow-rate control Parts can be fabricated in a single plane. Binder jet Large material range Near-ambient temperature process Part porosity can be tuned. Potential for high throughput and continuous...
Abstract
The application of three-dimensional printers can be revolutionary as a tool for the customization and personalization of pharmaceutical dosage forms. The areas of 3D printing applicable to pharmaceutical manufacturing can be segregated into three categories: extrusion technologies, powder-bed fusion, and stereolithography. Common extrusion-based technologies are fused deposition modeling and pressure-assisted microsyringe; powder-bed fusion is separated by binder jet and selective laser sintering. The synergies between pharmaceutical, or active pharmaceutical ingredient (API), and polymer printing are discussed in this article, with particular attention to how the incorporation of small-molecule APIs changes the material selection, design considerations, processing parameters, and challenges associated with each technology.
Series: ASM Handbook
Volume: 24A
Publisher: ASM International
Published: 30 June 2023
DOI: 10.31399/asm.hb.v24A.a0007021
EISBN: 978-1-62708-439-0
... method of metal powder production for AM. Gas atomization is preferred for AM feedstock because the powder is spherical with a good packing density and a reproducible, consistent particle size distribution (PSD). It enables large batch sizes with relatively high throughput. The PSD ranges are typically...
Abstract
This article provides an overview of the supply chain for metallic additively manufactured materials, with an emphasis on spherical alloy powders. The article describes powder production processes as well as the various metal alloys that can be produced using powder AM techniques. It also reviews the basic characteristics of powder feedstocks and the management of metallic powders.
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006855
EISBN: 978-1-62708-392-8
... and lung-cancer-associated fibroblasts were encapsulated into the hydrogel, and spheroid formation by the involved cells was observed. This system represents a suitable model for high-throughput drug-screening studies in tumor-therapy research ( Ref 39 ). Ivanovska et al. ( Ref 67 ) compared...
Abstract
This article discusses alginate/gelatin-based bioinks in 3D bioprinting applications, providing a summary of the most relevant previous work in the field. It presents advanced compositions to enhance functionality and/or optimize hydrogels for 3D bioprinting. The article discusses advanced printing techniques for alginate/gelatin-based bioinks.
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.9781627083928
EISBN: 978-1-62708-392-8
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006862
EISBN: 978-1-62708-392-8
... ) Vascular stents ( Ref 7 – 9 ) Surgical plates for jaw reconstruction ( Ref 10 ) Drug-delivery devices ( Ref 11 – 13 ) Personal protective equipment ( Ref 14 – 17 ) Furthermore, advancements in AM technologies have led to the fabrication of three-dimensional (3D)-printed tissues and organs...
Abstract
The article presents an in-depth discussion on the various additive manufacturing techniques such as binder jetting, directed-energy deposition, material extrusion, material jetting, powder-bed fusion, sheet lamination, and vat polymerization processes. This article then discusses the different critical material aspects of additively manufactured medical devices, beginning with the preprinting phase (material consistency and recycling), the printing phase (build orientation), and the postprinting phase (part evaluation, biocompatibility, and sterilization) with supporting materials.
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006860
EISBN: 978-1-62708-392-8
... to print single-cell patterns and 2D and 3D biological constructs. Such biological patterns and constructs have been used for various fields of interest related to cell and tissue dynamics, stem cell differentiation and development, and drug screening, to name a few. Single-Cell Printing...
Abstract
The use of 3D bioprinting techniques has contributed to the development of novel cellular patterns and constructs in vitro, ex vivo, and even in vivo. There are three main bioprinting techniques: inkjet printing, extrusion printing (also known as bioextrusion), laser-induced forward transfer (LIFT) printing, which is also known as modified LIFT printing, matrix-assisted pulsed-laser evaporation direct write, and laser-based printing (laser-assisted bioprinting, or biological laser printing). This article provides an overview of the LIFT process, including the LIFT process introduction, different implementations, jetting dynamics, printability phase diagrams, and printing process simulations. Additionally, materials involved during LIFT are introduced in terms of bioink materials and energy-absorbing layer materials. Also, the printing of single cells and 2D and 3D constructs is introduced, showcasing the current state of the art with the ultimate goal for tissue- and organ-printing applications.
Book Chapter
Series: ASM Desk Editions
Publisher: ASM International
Published: 01 November 1995
DOI: 10.31399/asm.hb.emde.a0003065
EISBN: 978-1-62708-200-6
... from “in-place procedures.” The high volume of inexpensive, more common glass products produced by these processes is usually made from soda-lime silicate glass compositions. These melting and forming processes provide a wide range of possibilities with respect to product quality and cost. Special...
Abstract
The large majority of the commercially important glasses are processed from a carefully calculated batch of raw materials that is then melted in special furnaces. Providing an introduction to melting practices of glass production, this article focuses on various finishing methods of glass products, including forming, grinding and polishing, and explores the advantages, disadvantages and steps involved in sol-gel process. It also discusses the types, processes and properties of annealed, laminated, and tempered glass, and presents the steps involved in glass decoration. The article gives a detailed account of production, properties and application of fiberglass, optical fibers, glass spheres and ceramic glasses, and describes the forms, classification, compositions and properties of glass/metal and glass-ceramic/metal seals.
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006893
EISBN: 978-1-62708-392-8
... bioprinting finds applications in soft/hard tissue engineering, regenerative medicine, tissue/organ transplantation, and clinical research high-throughput screening in pharmaceutical and cancer research. According to different droplet-forming principles, droplet-based bioprinting can be divided into inkjet...
Abstract
This article focuses on the pneumatic extrusion-based system for biomaterials. It provides an overview of additive manufacturing (AM) processes, followed by sections covering steps and major approaches for the 3D bioprinting process. Then, the article discusses the types, processes, advantages, limitations, and applications of AM technology and extrusion-based approaches. Next, it provides information on the research on extrusion-based printing. Finally, the article provides a comparison of the extrusion-based approach with other approaches.
Series: ASM Handbook
Volume: 24
Publisher: ASM International
Published: 15 June 2020
DOI: 10.31399/asm.hb.v24.a0006565
EISBN: 978-1-62708-290-7
... required is on the order of an individual voxel, LIFT based on LDT is required. The application of LIFT for the printing of high-viscosity (100,000 cP) silver nanopastes developed for screen printing applications results in the transfer of voxels exhibiting sharp edges that resemble lithographically...
Abstract
This article discusses the basic operating principles, industrial applications, and advantages as well as the parameters influencing the process of laser-induced forward transfer (LIFT) of solid materials, liquid materials, laser-absorbing layers, intact structures, and metallic 3D microstructures in additive manufacturing.
Series: ASM Handbook
Volume: 10
Publisher: ASM International
Published: 15 December 2019
DOI: 10.31399/asm.hb.v10.9781627082136
EISBN: 978-1-62708-213-6
Series: ASM Handbook Archive
Volume: 10
Publisher: ASM International
Published: 01 January 1986
DOI: 10.31399/asm.hb.v10.9781627081788
EISBN: 978-1-62708-178-8
Series: ASM Handbook
Volume: 24A
Publisher: ASM International
Published: 30 June 2023
DOI: 10.31399/asm.hb.v24A.9781627084390
EISBN: 978-1-62708-439-0
Series: ASM Handbook
Volume: 24
Publisher: ASM International
Published: 15 June 2020
DOI: 10.31399/asm.hb.v24.9781627082907
EISBN: 978-1-62708-290-7