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biological response

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Published: 12 September 2022
Fig. 10 Comparative biological response evaluation of CoCr alloys and CoCr-calcium phosphate (CaP)-reinforced alloys. (a) Enhanced MTT osteoblast viability for CoCr after CaP addition. (b) Enhanced osteoid formation at 5 weeks postimplantation of CoCr and CoCr-CaP alloys. (c) Enhanced bone More
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006889
EISBN: 978-1-62708-392-8
... biomedical-based devices: binder jetting, powder-bed fusion, and directed-energy deposition. The article then characterizes the electrochemical properties of additive-manufactured/processed cobalt-chromium alloys. This is followed by sections providing an evaluation of the biological response to CoCr alloys...
Series: ASM Handbook
Volume: 13C
Publisher: ASM International
Published: 01 January 2006
DOI: 10.31399/asm.hb.v13c.a0004208
EISBN: 978-1-62708-184-9
... Abstract This article provides information on biomedical aspects such as active biological responses and the chemical environment characterizing the internal physiological milieu, as well as electrochemical fundamentals needed for characterizing corrosion fatigue (CF) and stress-corrosion...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005659
EISBN: 978-1-62708-198-6
... Abstract This article provides a summary of the biocompatibility or biological response of metals, ceramics, and polymers used in medical implants, along with their clinical issues. The polymers include ultrahigh-molecular-weight polyethylene, nonresorbable polymer, and resorbable polymers...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005667
EISBN: 978-1-62708-198-6
... Abstract This article discusses several aspects of biocompatibility of polymers, including the selection of a suitable polymer, specific use of a material, contact of polymer on body site, and duration of the contact. It describes the factors influencing the biological response of the polymer...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005666
EISBN: 978-1-62708-198-6
... addresses the biologic aspects of implant debris, both locally and systemically. It describes debris-induced local effects, particle-induced proinflammatory responses, and debris-induced systemic effects. The article concludes with a discussion on the four systemic effects of implant debris, namely...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005686
EISBN: 978-1-62708-198-6
... that are commonly used in the risk assessment process are discussed. These include hazard identification, dose-response assessment, and exposure assessment, and risk characterization. biological evaluation chemical characterization dose-response assessment exposure assessment hazard identification...
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006853
EISBN: 978-1-62708-392-8
... ). Biofunctionalization Biomimetic surface modification, also called biofunctionalization, involves immobilization of biomolecules on the surface to change their biochemical properties and biological responses. Biofunctionalization also allows anchorage of organic components such as proteins, enzymes, and peptides...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005655
EISBN: 978-1-62708-198-6
...-TCP has also been combined with HA to form biphasic calcium phosphate ceramics, which allow for better control of the resorption rate and improved biological properties ( Ref 40 ). Tissue Response to Bioceramics After implantation, the first response of the human body to a foreign object...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005682
EISBN: 978-1-62708-198-6
... responses to the biomaterial. It discusses the testing methods of implant failure, such as in vitro and in vivo assessment of tissue compatibility. biomaterials biomedical devices cardiovascular applications ceramic implants dental applications functionally-graded hip implant implant failure...
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006908
EISBN: 978-1-62708-392-8
..., printing characteristics and parameters as well as postprinting validation; removal of the many manufacturing material residues and sterilization; physical, chemical, and mechanical assessments of the final devices; and biological considerations of all the final devices including biocompatibility...
Series: ASM Handbook
Volume: 18
Publisher: ASM International
Published: 31 December 2017
DOI: 10.31399/asm.hb.v18.a0006404
EISBN: 978-1-62708-192-4
... of macrophage phagocytosis of wear particles induces human biological/physiological responses that eventually lead to bone resorption and osteolysis, which is one of the major complications in TKR. In addition to the mechanical design and the type of knee replacement, sterilization methods can have...
Series: ASM Handbook
Volume: 13C
Publisher: ASM International
Published: 01 January 2006
DOI: 10.31399/asm.hb.v13c.a0004207
EISBN: 978-1-62708-184-9
... that the semiconductivity of oxide films influences the thrombogeneity of artificial materials in terms of band energy and surface states. Inflammatory Response to Biomaterials Recent research ( Ref 58 , 59 ) reviewed the biological responses to materials and found that there is a sequence of host reactions...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005675
EISBN: 978-1-62708-198-6
... Possible tissue responses to biomedical implants Implant material characteristics Tissue response Applications Biologically inactive Fibrous tissue of variable thickness forms (a) No Biologically sustainable Cells are attached and proliferated Artificial organs (hybrid type)  Porous...
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006905
EISBN: 978-1-62708-392-8
... additive manufacturing products with complex shapes involving hollow structures difficult to produce using conventional removal and molding techniques Biological responses to structures fabricated by laser powder-bed fusion (L-PBF) and electron beam powder-bed fusion (EB-PBF) Table 1 Biological...
Series: ASM Handbook
Volume: 13C
Publisher: ASM International
Published: 01 January 2006
DOI: 10.31399/asm.hb.v13c.a0004205
EISBN: 978-1-62708-184-9
... Abstract In the field of medical device development and testing, the corrosion of metallic parts can lead to significant adverse effects on the biocompatibility of the device. This article describes the mechanisms of metal and alloy biocompatibility. It reviews the response of implant metals...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005652
EISBN: 978-1-62708-198-6
... Abstract This article discusses the mechanisms of metal and alloy biocompatibility. It provides information on early testing and experience with metals in medical device applications. The article describes the response of implant and particulate materials to severe corrosion. It provides...
Series: ASM Handbook
Volume: 23
Publisher: ASM International
Published: 01 June 2012
DOI: 10.31399/asm.hb.v23.a0005665
EISBN: 978-1-62708-198-6
... of transition metals such as chromium, cobalt, and vanadium to improve their physical and mechanical properties, as well as their subsequent alteration in aggressive biological environments, should be addressed. The release of toxic ions in different oxidative states generated by these transition metals through...
Series: ASM Handbook
Volume: 13A
Publisher: ASM International
Published: 01 January 2003
DOI: 10.31399/asm.hb.v13a.a0003637
EISBN: 978-1-62708-182-5
.... These organisms include many species of bacteria, algae, and fungi. In all of these environments, the tendency is for microorganisms present in the water to attach to and grow on the immersed surfaces of structural materials, resulting in the formation of a biological film, or biofilm. Larger, macroscopic...
Series: ASM Handbook
Volume: 23A
Publisher: ASM International
Published: 12 September 2022
DOI: 10.31399/asm.hb.v23A.a0006887
EISBN: 978-1-62708-392-8
... Abstract Stereolithographic (STL) additive manufacturing (AM) can be used to fabricate practical components. This article discusses the processes involved in STL-AM of biological scaffolds, providing information on bioscaffold processing, cavity arrangements, and microlattice distributions...