This article first describes a typical additive manufacturing (AM) process chain, which involves the transaction of digital information to manufacture physical products. The digitized nature of AM exposes the technology to increased vulnerabilities, posing a hurdle to its mass adoption. The article presents motivation for using blockchain, which is a decentralized, immutable ledger that is shared on a peer-to-peer network. The article presents the advantages of blockchain integration to AM supply chains. These involve aspects of data security, supply chain and logistics, finance, value creation, and scope expansion. The article also presents the opportunities and challenges of blockchain technology.

Additive manufacturing (AM) processes fabricate parts in a layer-by-layer manner by which materials are added and processed repeatedly. This article introduces the general concepts and approaches to design for AM (DFAM) and outlines important implications for part characteristics, design opportunities, manufacturing practices, supply chains, and even business models. It presents contrasting perspectives on DFAM, followed by a discussion on more general and overarching opportunistic design methods and on design for constraints, similar to conventional DFM. It concludes with a presentation of a design approach to the AM process chain, acknowledging that AM-fabricated parts typically undergo several postprocessing steps and that it is important to design taking into account these steps.

Additive manufacturing (AM) offers expansive design freedoms for realizing parts that are more complex and customized than their conventionally fabricated counterparts, but all AM technologies impose restrictions on buildable geometries and features. Design rules capture those restrictions in the form of best practices to successfully design for AM. This article discusses how design rules can potentially support and accelerate the process of developing part geometry for AM. The discussion provides examples of design rules that are independent of any specific AM process and then discusses design rules specific to particular AM processes.

This article focuses on two streams of the research on part consolidation (PC): PC in the conventional manufacturing context, and PC in the additive manufacturing (AM) context. It reviews the challenges of applying AM-PC potentials. The article includes research literature on the selection of part candidates for consolidation and summarizes the conversion of assembly design to consolidated design. Then, a holistic approach for supporting PC design is introduced with integrated modules of part filtering and fusion of parts. Details of the key techniques of the two modules are later introduced with a gas pedal example. Finally, emerging trends in PC research are discussed.

Additive manufacturing (AM) provides exceptional design flexibility, enabling the manufacture of parts with shapes and functions not viable with traditional manufacturing processes. The two paradigms aiming to leverage computational methods to design AM parts imbuing the design-for-additive-manufacturing (DFAM) principles are design optimization (DO) and simulation-driven design (SDD). In line with the adoption of AM processes by industry and extensive research efforts in the research community, this article focuses on powder-bed fusion for metal AM and material extrusion for polymer AM. It includes detailed sections on SDD and DO as well as three case studies on the adoption of SDD, DO, and artificial-intelligence-based DFAM in real-life engineering applications, highlighting the benefits of these methods for the wider adoption of AM in the manufacturing industry.

This article provides an introduction to architected cellular materials, their design, fabrication, and application domain. It discusses design decisions involving the selection, sizing, and spatial distribution of the unit cell, property-scaling relationships, and the integration of cells within an external boundary. It describes how manufacturing constraints influence achievable feature resolution, dimensional accuracy, properties, and defects. It also discusses the mechanical behavior of architected cellular materials and the role of additive manufacturing in their fabrication.

The article presents an in-depth discussion on the various additive manufacturing techniques such as binder jetting, directed-energy deposition, material extrusion, material jetting, powder-bed fusion, sheet lamination, and vat polymerization processes. This article then discusses the different critical material aspects of additively manufactured medical devices, beginning with the preprinting phase (material consistency and recycling), the printing phase (build orientation), and the postprinting phase (part evaluation, biocompatibility, and sterilization) with supporting materials.

Additive manufacturing (AM) techniques include powder-bed fusion (PBF), directed-energy deposition, binder jetting (BJ), extrusion-based desktop, vat photopolymerization, material jetting, and sheet lamination. The development of suitable powders for AM is a challenging task because of critical design parameters including chemical composition, flowability of powders, and melt surface tension. This article explains the fabrication methods of metal and novel alloy powders for medical applications. The development of zirconium alloy powder for laser-PBF is introduced as a case study.

Powder-bed fusion (PBF) is a group of additive manufacturing (AM) processes that includes selective laser sintering, selective laser melting, and electron beam melting. This article explains the processes and parameters of PBF systems that are used for biomedical applications. It also presents the desirable properties of biomedical devices and the advantages of using PBF systems for biomedical applications.

Additive manufacturing (AM), or three-dimensional (3D) printing, has been widely used for biomedical devices due to its higher freedom of design and its capability for mass customization. Additive manufacturing can be broadly classified into seven categories: binder jetting, directed energy deposition (DED), material extrusion, material jetting, powder-bed fusion (PBF), sheet lamination, and vat photopolymerization. Due to their capability for manufacturing high-quality parts that are fully dense, PBF and DED are the most widely used groups of AM techniques in processing metals directly. In this article, the processing of titanium and its alloys by PBF and DED is described, with a specific focus on their use in biomedical devices. The article then covers the density and mechanical properties of both commercially pure titanium and titanium-aluminum-vanadium alloy. Lastly, the challenges and potential of using new titanium-base materials are discussed.

Three-dimensional plotting of biomaterials (also known as bioprinting) has been a major milestone for scientists and engineers working in nanobiotechnology, nanoscience, and nanomedicine. It is typically classified into two major categories, depending on the plotting principle, as contact and noncontact techniques. This article focuses on the working principles of contact and noncontact printing methods along with their advantages, disadvantages, applications, and challenges. Contact printing methods include micro-plotter, pen printing, screen printing, nanoimprint printing, flexography printing, and gravure printing. Noncontact printing methods include extrusion printing, droplet printing, laser-based polymerization, and laser-based cell transfer. The wide variety of printable biomaterials, such as DNA, peptides, proteins, lipids, and cells, also are discussed.

This article begins with a description of extrusion-based bioprinting for tissue scaffold fabrication. It also examines various extrusion-based bioprinting processes and related tissue scaffolding strategies, presents the selection criteria of various bioinks with various polymers and their printed scaffolds for applications in tissue engineering and regenerative medicines, and provides future research recommendations to address the shortcomings and issues found in current extrusion-based bioprinting processes.

This article discusses alginate/gelatin-based bioinks in 3D bioprinting applications, providing a summary of the most relevant previous work in the field. It presents advanced compositions to enhance functionality and/or optimize hydrogels for 3D bioprinting. The article discusses advanced printing techniques for alginate/gelatin-based bioinks.

Due to its layer-by-layer process, 3D printing enables the formation of complex geometries using multiple materials. Three-dimensional printing for bone tissue engineering is called bioprinting and refers to the use of material-transfer processes for patterning and assembling biologically relevant materials, molecules, cells, tissues, and biodegradable biomaterials with a prescribed organization to accomplish one or more biological functions. Currently, 3D bioprinting constructs can be classified into two categories: acellular and cellular. This article introduces and discusses these two approaches based on the suitable materials for these constructs and the fabrication processes used to manufacture them. The materials are grouped into polymers, metals, and hydrogels. The article also summarizes the commonly used 3D printing techniques for these materials, as well as cell types used for various applications. Lastly, current challenges in tissue engineering are discussed.

Additive manufacturing (AM), or three-dimensional (3D) printing, is a class of manufacturing processes that create the desired geometries of an object, or an assembly of objects, layer by layer or volumetrically. AM has been used extensively for manufacturing medical devices, due to its versatility to satisfy the specific needs of an intended medical field for the product/device. This article provides a comprehensive review of AM in medical devices by the medical specialty panels of the Food and Drug Administration (FDA) Code of Federal Regulations, Parts 862 to 892, including anesthesiology, ear and nose, general hospital, ophthalmic, plastic surgery, radiology, cardiovascular, orthopedic, dental, neurology, gynecology, obstetrics, physical medicine, urology, toxicology, and pathology. It is classified under these panels, and critical reviews and future outlooks are provided. The application of AM to fabricate medical devices in each panel is reviewed; lastly, a comparison is provided to reveal relevant gaps in each medical field.

Vat polymerization is a form of three-dimensional (3D) printing. Historically, it is the oldest additive manufacturing technique, with the development of stereolithography apparatus (SLA) by Charles Hull in 1986. This article outlines the various forms of vat polymerization techniques used for biomedical applications. Due to the complex nature of this printing process, many key print parameters and material properties need to be considered to ensure a successful print. These influential parameters are addressed throughout the article to inform the reader of the considerations that should be taken when using the vat polymerization technique. The article provides information on vat polymerization printer setup, the photo-cross-linking mechanism, and considerations using vat polymerization. In addition, it outlines and discusses the advancements of vat polymerization in the biomedical industry.

According to International Organization for Standardization (ISO)/ASTM International 52900, additive manufacturing (AM) can be classified into material extrusion, material jetting, vat photo polymerization, binder jetting, sheet lamination, powder-bed fusion (PBF), and directed-energy deposition. This article discusses the processes involved in polymer powder 3D printing using laser fusion/ sintering and fusing agents and energy, as well as the thermally fused PBF. It provides information on polymer powder parameters and modeling, the powder-handling system, powder characterization, the flowability of powder feedstock, and polymer part characteristics. The article describes the types of polymers in PBF, the processes involved in powder recycling, and the prospects of PBF in AM. In addition, the biomedical application of polyether ether ketone (PEEK) is also covered.

Additive manufacturing (AM) technologies print three-dimensional (3D) parts through layer-by-layer deposition based on the digital input provided by a computer-aided design file. This article focuses on the binder jet printing process, common biomaterials used in this AM technique, and the clinical applications relevant to these systems. It reviews the challenges and future directions of binder-jetting-based 3D printing.