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This article discusses the mechanisms of metal and alloy biocompatibility. It provides information on early testing and experience with metals in medical device applications. The article describes the response to severe corrosion of implant and particulate materials. It provides a description of metal binding and its effects on metabolic processes. The hypersensitive responses to metal ions are also reviewed. The article concludes with a discussion on possible cancer-causing effects of metallic biomaterials.

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Kenneth R. St. John, Biocompatibility of Metallic Materials for Medical Devices—The Effects of Corrosion and Corrosion Products, Materials for Medical Devices, Vol 23, ASM Handbook, Edited By Roger J. Narayan, ASM International, 2012, p 73–78,

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