The hazards associated with thermal spray deposition processes include ultraviolet and infrared radiation; acoustical noise; and by-product production in the forms of nitrous oxides, ozone, fumes, and dust. The most important consideration in health and safety is to use the engineered controls of hazards. This article provides a brief description of the spray booth, the most commonly used engineering tool to separate the operator from the thermal spray process and confine the associated hazards. It also presents guidelines on the proper and safe handling of industrial gases and ventilation and heat exhaust. The article provides information on the personal protective equipment for eyes and skin from radiation, and ears from noise. It also discusses other potential safety hazards associated with thermal spraying, namely, magnetic fields and infrasound.