This article discusses the safety issues associated with the design and operation of thermal spray booths and spray box structures and the equipment or systems required for operating thermal spray processes. It describes the design elements necessary to mitigate sound, dust and fume, ultraviolet light, and mechanical hazards. The means selected for safeguarding personnel must be based on a formal risk assessment that meets ANSI/RIA standards. The safeguards include sensing devices, barriers, awareness signals, procedures, and training. It also provides guidelines that are intended to increase the safety awareness and the use of safety practices for gas and liquid piping and electrical equipment within thermal spray installations.