Homogenization heat treatment can be useful for improving the performance and life of an alloy while in service or for improving the processability during fabrication and hot working. This article describes the identification of incipient melt point, slowest-diffusing elements, and microstructural scale for homogenization of metal alloys. It also discusses the CALPHAD software to optimize the homogenization heat treatment and the Scheil module of the commercial thermodynamic modeling software.