Microjoining methods are commonly used to fabricate medical components and devices. This article describes key challenges involved during microjoining of medical device components. The primary mechanisms used in microjoining for medical device applications include microresistance spot welding (MRSW) and laser welding. The article illustrates the fundamental principles involved in MRSW and laser welding. Most multicomponent medical devices implement microjoining techniques to join various forms of materials and geometries. The article presents examples of various microjoining methods used in medical device applications, including pacemaker and nitinol microscopic forceps.